Citation:
Jones D, Wakeley J. The influence of gene conversion on linkage disequilibrium around a selective sweep. Genetics. 2008;180 (2) :1251-1259.
(pdf) | 555 KB |
Abstract:
In a 2007 article, McVean studied the effect of recombination on linkage disequilibrium (LD) between
two neutral loci located near a third locus that has undergone a selective sweep. The results demonstrated that two loci on the same side of a selected locus might show substantial LD, whereas the expected LD for two loci on opposite sides of a selected locus is zero. In this article, we extend McVean’s model to include gene conversion. We show that one of the conclusions is strongly affected by gene conversion: when gene conversion is present, there may be substantial LD between two loci on opposite sides of a selective sweep.