The influence of gene conversion on linkage disequilibrium around a selective sweep.

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Abstract:

In a 2007 article, McVean studied the effect of recombination on linkage disequilibrium (LD) between

two neutral loci located near a third locus that has undergone a selective sweep. The results demonstrated that two loci on the same side of a selected locus might show substantial LD, whereas the expected LD for two loci on opposite sides of a selected locus is zero. In this article, we extend McVean’s model to include gene conversion. We show that one of the conclusions is strongly affected by gene conversion: when gene conversion is present, there may be substantial LD between two loci on opposite sides of a selective sweep. 

Last updated on 10/25/2016