Pairwise differences under a general model of population subdivision.

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Abstract:

A number of different migration and isolation models of population subdivision have been studied. In this paper I analyse a general model of two populations derived from a common ancestral population at some time in the past. The two populations may exchange migrants, but they may also be completely isolated from each other. I derive the expectation and variance of the number of differences between two sequences sampled from the two populations. These are then compared to the corresponding results from two other much-used models: equilibrium migration and complete isolation.

Last updated on 12/16/2015