# Wakeley Lab ![gijt_2.png](/sites/g/files/omnuum5776/files/styles/hwp_1_1__960x960_scale/public/wakeleylab/files/gijt_2.png?itok=ZPbU4iIv) ## Welcome We are devoted to the study of theoretical population genetics. The goal of population genetics is to identify and understand the forces that produce and maintain genetic variation in natural populations. These forces include mutation (also recombination and gene conversion), natural selection, various kinds of population structure (e.g. subdivision with migration), and the random fluctuations of gene frequencies through time known as genetic drift. We study these forces mathematically, using both analysis and computation. We also develop statistical methods to make inferences about these forces from DNA sequences or other kinds of genetic data. A recent area of focus has been to describe how the genealogy of individuals in a population, also called the population pedigree, affects gene genealogies and patterns of genetic variation in samples from the population. ## Recent Publications Download 5 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1573776&content_filter%5B1%5D=1573761&content_filter%5B2%5D=1573756&content_filter%5B3%5D=1565956&content_filter%5B4%5D=1535246&&format=ris) ### 2025 Newman M, Wakeley J, Fan W-T. [Conditional gene genealogies given the population pedigree for a diploid Moran model with selfing](/publication/conditional-gene-genealogies-given-population-pedigree-diploid-moran-model-selfing). *Theoretical Population Biology*. 2025;165:29-44. Newman M, Wakeley J, Fan W-T. [Conditional gene genealogies given the population pedigree for a diploid Moran model with selfing](/publication/conditional-gene-genealogies-given-population-pedigree-diploid-moran-model-selfing). *Theoretical Population Biology*. 2025;165:29-44. - [Publisher's version (with free access though Sept 10, 2025)](https://authors.elsevier.com/c/1lUEB9EXxdegp) - [Publisher's version (with free access though Sept 10, 2025)](https://authors.elsevier.com/c/1lUEB9EXxdegp) ### 2024 Fan W-T, Wakeley J. [Latent mutations in the ancestries of alleles under selection](/publication/latent-mutations-ancestries-alleles-under-selection). *Theoretical Population Biology*. 2024;158:20. Fan W-T, Wakeley J. [Latent mutations in the ancestries of alleles under selection](/publication/latent-mutations-ancestries-alleles-under-selection). *Theoretical Population Biology*. 2024;158:20. - [(pdf)](/sites/g/files/omnuum5776/files/2025-08/FanAndWakeley2024.pdf) - [(pdf)](/sites/g/files/omnuum5776/files/2025-08/FanAndWakeley2024.pdf) Rivas-González I, Schierup M, Wakeley J, Hobolth A. [TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting](/publications/trails-tree-reconstruction-ancestry-using-incomplete-lineage-sorting). *PLOS Genetics*. 2024;20(2):1-21. Rivas-González I, Schierup M, Wakeley J, Hobolth A. [TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting](/publications/trails-tree-reconstruction-ancestry-using-incomplete-lineage-sorting). *PLOS Genetics*. 2024;20(2):1-21. - [Publisher's version (open access)](https://doi.org/10.1371/journal.pgen.1010836) - [Publisher's version (open access)](https://doi.org/10.1371/journal.pgen.1010836) Diamantidis D, Fan W-T, Birkner M, Wakeley J. [Bursts of coalescence within population pedigrees whenever big families occur](/publications/bursts-coalescence-within-population-pedigrees-whenever-big-families-occur). *Genetics*. 2024:iyae030. Diamantidis D, Fan W-T, Birkner M, Wakeley J. [Bursts of coalescence within population pedigrees whenever big families occur](/publications/bursts-coalescence-within-population-pedigrees-whenever-big-families-occur). *Genetics*. 2024:iyae030. - [ picture\_as\_pdfAccepted Manuscript](/sites/g/files/omnuum5776/files/wakeleylab/files/iyae030.pdf) - [ picture\_as\_pdfAccepted Manuscript](/sites/g/files/omnuum5776/files/wakeleylab/files/iyae030.pdf) ### 2023 Wakeley J, Fan W-T, Koch E, Sunyaev S. [Recurrent mutation in the ancestry of a rare variant](/publications/recurrent-mutation-ancestry-rare-variant). *Genetics*. 2023;224:iyad049. Wakeley J, Fan W-T, Koch E, Sunyaev S. [Recurrent mutation in the ancestry of a rare variant](/publications/recurrent-mutation-ancestry-rare-variant). *Genetics*. 2023;224:iyad049. - [Publisher's version (open access)](https://academic.oup.com/genetics/article/224/3/iyad049/7086184) - [Publisher's version (open access)](https://academic.oup.com/genetics/article/224/3/iyad049/7086184)